SU11274

MET is a proto-oncogene which encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. SU11274 is a potent, selective, ATP-competitive inhibitor of c-Met (IC50 = 20 nM). It has much less or no activity against other receptor tyrosine kinases. SU11274 induces apoptosis and cell cycle arrest in transformed Ba/F3 cells and cancer cell lines.Formal Name: (3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide. CAS Number: 658084-23-2. Synonyms: Met Kinase Inhibitor. Molecular Formula: C28H30ClN5O4S. Formula Weight: 568.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml, DMSO: 11 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 300, 439 nm. SMILES: ClC1=CC(N(C)S(C2=CC=C(NC(/C3=C\C4=C(C)C(C(N5CCN(C)CC5)=O)=C(C)N4)=O)C3=C2)(=O)=O)=CC=C1. InChi Code: InChI=1S/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13-34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37,38)33(4)20-7-5-6-19(29)14-20/h5-9,14-16,30H,10-13H2,1-4H3,(H,31,35)/b23-16-. InChi Key: FPYJSJDOHRDAMT-KQWNVCNZSA-N.