STING Agonist D61

STING agonist D61 (D61) is an agonist of stimulator of interferon genes (STING). It induces expression of an IFN3-inducible secreted alkaline phosphatase (SEAP) reporter gene and an IFN-beta-inducible reporter gene in cell-based assays (EC50s = 52.9 and 116 nM, respectively). D61 (4, 6, and 8 µM) increases the expression of mRNA encoding IFN-beta and chemokine (C-X-C motif) ligand 10 (CXCL10) and phosphorylation of TANK-binding kinase 1 (TBK1), IRF3, and STING in THP-1 monocytes. In vivo, D61 (0.25 mg/kg every other day) reduces tumor volume without affecting body weight in a CT26 murine colon cancer model.Formal Name: 2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1-[3-fluoromethyl)phenyl]-2-oxazolyl]amino]propyl]. CAS Number: 2850251-27-1. Synonyms: D61, Stimulator of Interferon Genes Agonist D61. Molecular Formula: C29H29F3N8O4. Formula Weight: 610.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. lambdamax: 322 nm. SMILES: COC1=C2C(N=C(NC(C3=CC(C)=NN3CC)=O)N2CCCNC4=NC=C(C5=C(C(F)(F)F)C=CC=C5)O4)=CC(C(N)=O)=C1. InChi Code: InChI=1S/C29H29F3N8O4/c1-4-40-21(12-16(2)38-40)26(42)37-27-36-20-13-17(25(33)41)14-22(43-3)24(20)39(27)11-7-10-34-28-35-15-23(44-28)18-8-5-6-9-19(18)29(30,31)32/h5-6,8-9,12-15H,4,7,10-11H2,1-3H3,(H2,33,41)(H,34,35)(H,36,37,42). InChi Key: SAIPDXPIJPBWOT-UHFFFAOYSA-N.