STING Agonist 12L

STING agonist 12L is an agonist of stimulator of interferon genes (STING). It binds to wild-type STING (IC50 = 1.15 µM), as well as the STING R232, AQ, and Q variants (IC50s = 1.06, 0.61, and 1.12 µM, respectively) and induces reporter gene expression in THP-1 and RAW 264.7 cells (EC50s = 0.38 and 12.94 µM, respectively). STING agonist 12L (5 µM) induces IFNB1, CXCL10, and IL6 mRNA expression in THP-1 cells. In vivo, STING agonist 12L (10 mg/kg) increases plasma IFN-beta levels and reduces tumor volume and the number of lung metastases in a B16/F10 murine melanoma model.Formal Name: 2-([3,4'-bipyridazine]-6-carboxamido)-4-ethynyl-5-fluorobenzoic acid. CAS Number: 2913152-30-2. Synonyms: Stimulator of Interferon Genes Agonist 12L. Molecular Formula: C18H10FN5O3. Formula Weight: 363.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 2 mg/ml. SMILES: O=C(O)C1=CC(F)=C(C#C)C=C1NC(C2=NN=C(C3=CC=NN=C3)C=C2)=O. InChi Code: InChI=1S/C18H10FN5O3/c1-2-10-7-16(12(18(26)27)8-13(10)19)22-17(25)15-4-3-14(23-24-15)11-5-6-20-21-9-11/h1,3-9H,(H,22,25)(H,26,27). InChi Key: KEGLNBCLJXFLRV-UHFFFAOYSA-N.