STF-083010

STF-083010 is an inhibitor of the IRE1/XBP1 pathway, blocking IRE1 endonuclease activity without affecting its kinase activity after endoplasmic reticulum (ER) stress both in vitro and in vivo. STF-083010 (60 µM) reduces the splicing of XBP1 by IRE1 in the presence of thapsigargin (Cay-10522), an ER stress inducer. This has cytotoxic effects against multiple myeloma cells and drives apoptosis in pancreatic cancer cells.Formal Name: N-[(2-hydroxy-naphthalenyl)methylene]-2-thiophenesulfonamide. CAS Number: 307543-71-1. Synonyms: IRE1 Inhibitor I. Molecular Formula: C15H11NO3S2. Formula Weight: 317.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMF:PBS (pH 7.2) (1:7): 0.12 mg/ml, DMSO: 1 mg/ml. lambdamax: 224, 249, 338, 384 nm. SMILES: O=S(/N=C/C1=C2C(C=CC=C2)=CC=C1O)(C3=CC=CS3)=O. InChi Code: InChI=1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+. InChi Key: TVIVJHZHPKNDAQ-MHWRWJLKSA-N.