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ST034307 is an inhibitor of adenylyl cyclase 1 (AC1), a membrane-bound AC, with an IC50 value of 2.3 µM for A23187-stimulated cAMP accumulation in HEK293 cells transfected with AC1. It also inhibits AC1 activation induced by forskolin (Cay-11018) or isoproterenol (Cay-15592) in vitro. It is selective for AC1 over other membrane-bound AC isoforms. ST034307 enhances the inhibition of AC1 by the µ-opioid receptor (MOR) agonist DAMGO (Cay-21553) in HEK293 cells transfected with AC1 and MOR. In a mouse model of inflammatory pain, ST034307 reduces hypersensitivity to touch in mouse hind paw (ED50 = 0.28 µg), which is blocked by forskolin.Formal Name: 6-chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one. CAS Number: 133406-29-8. Molecular Formula: C10H4Cl4O2. Formula Weight: 298.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 5 mg/ml. lambdamax: 230, 312 nm. SMILES: O=C1C2=CC(Cl)=CC=C2OC(C(Cl)(Cl)Cl)=C1. InChi Code: InChI=1S/C10H4Cl4O2/c11-5-1-2-8-6(3-5)7(15)4-9(16-8)10(12,13)14/h1-4H. InChi Key: NTDHYMSVCBGQJF-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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