Src Kinase Inhibitor I

The Src kinases constitute a family of non-receptor tyrosine kinases, which includes Src and Lck. Src kinase inhibitor I is a potent competitive inhibitor of both Src and Lck (IC50 = 44 and 88 nM, respectively), as well as Csk and Yes. It less effectively blocks the receptor tyrosine kinases VEGFR2 and C-fms (IC50 = 0.32 and 30 µM), as well as a long list of serine/threonine kinases. Src kinase inhibitor I also inhibits receptor-interacting protein-2 with an IC50 value of 26 nM.Formal Name: 6,7-dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine. CAS Number: 179248-59-0. Molecular Formula: C22H19N3O3. Formula Weight: 373.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.25 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml, DMSO: 2.5 mg/ml. lambdamax: 223, 253, 344 nm. SMILES: COC1=C(OC)C=C(N=CN=C2NC3=CC=C(OC4=CC=CC=C4)C=C3)C2=C1. InChi Code: InChI=1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25). InChi Key: DMWVGXGXHPOEPT-UHFFFAOYSA-N.