SR 59230A (hydrochloride)

SR 59230A (hydrochloride) is a beta3-adrenergic receptor (beta3-AR) antagonist (pA2s = 8.76, 7.31, and 6.63 in rat proximal colon, guinea pig atrium, and guinea pig trachea, respectively). It is less selective for beta3-AR in cells transfected with the human beta-AR subtypes (Kis = 16.4, 61.9, and 122 nM for beta1-, beta2-, and beta3-AR, respectively). At low concentrations, SR 59230A blocks MDMA-induced hyperthermia, while at high concentrations it blocks hyperthermia but also increases heat loss through an alpha1-AR antagonistic mechanism. In adipocytes, it induces phosphorylation of p38 MAPK via the Gs pathway. It has also been used in studies of heart failure to elucidate the role of the beta3-ARs.Formal Name: (2S)-1-(2-ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-2-propanol, monohydrochloride. CAS Number: 1135278-41-9. Molecular Formula: C21H27NO2 . HCl. Formula Weight: 361.9. Purity: >99%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Water: 10 mM. SMILES: CCC1=C(OC[C@H](CN[C@H]2CCCC3=C2C=CC=C3)O)C=CC=C1.Cl. InChi Code: InChI=1S/C21H27NO2.ClH/c1-2-16-8-4-6-13-21(16)24-15-18(23)14-22-20-12-7-10-17-9-3-5-11-19(17)20,/h3-6,8-9,11,13,18,20,22-23H,2,7,10,12,14-15H2,1H3,1H/t18-,20-,/m0./s1. InChi Key: SHUCXUIOEAAJJL-MKSBGGEFSA-N.