Spermine

Spermine is an endogenous polyamine synthesized from the reaction of spermidine (Cay-14918) with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis. Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.Formal Name: N1,N4-bis(3-aminopropyl)-1,4-butanediamine. CAS Number: 71-44-3. Synonyms: Gerontine, Musculamine, Neuridine, NSC 268508, 1,5,10,14-Tetraazatetradecane. Molecular Formula: C10H26N4. Formula Weight: 202.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 50 mg/ml. SMILES: NCCCNCCCCNCCCN. InChi Code: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2. InChi Key: PFNFFQXMRSDOHW-UHFFFAOYSA-N.