SP 600125, negative control

Description: SP 600125, negative control is a methylated analog of SP 600125 and can be used as a negative control for SP 600125. SP 600125, negative control inhibits DTP3 and GADD45beta/MKK7 (growth arrest and DNA damage-inducible beta/mediator-activated protein kinase kinase kinase 7) and is capable of restoring activation.The IC50s of SP 600125, negative control against JNK2 and JNK3 were 18 and 24 µM, respectively. Target: Others. Smiles: O=C1C=2C=3C(C=4C1=CC=CC4)=NN(C)C3C=CC2. References: Zhang Y, et al. Suppression of delayed rectifier K+ channels by gentamicin induces membrane hyperexcitability through JNK and PKA signaling pathways in vestibular ganglion neurons. Biomed Pharmacother. 2021,135:111185.