SP-420

SP-420 is an iron chelator and a derivative of desferrothiocin. It induces iron excretion in rat bile and urine with an iron-clearing efficiency (ICE) value of 26.7% when administered at a dose of 300 µmol/kg and decreases iron levels in rat liver and heart at 384 µmol/kg per day. SP-420 (75 µmol/kg) also induces iron excretion in iron-overloaded C. apella monkeys (ICE = 26.3%).Formal Name: (4S)-4,5-dihydro-2-[2-hydroxy-4-[2-(2-methoxyethoxy)ethoxy]phenyl]-4-methyl-4-thiazolecarboxylic acid. CAS Number: 911714-45-9. Synonyms: (S)-4'-(HO)-DADFT-norPE. Molecular Formula: C16H21NO6S. Formula Weight: 355.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, Ethanol: 15 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 214, 273, 309 nm. SMILES: OC1=CC(OCCOCCOC)=CC=C1C2=N[C@](C(O)=O)(C)CS2. InChi Code: InChI=1S/C16H21NO6S/c1-16(15(19)20)10-24-14(17-16)12-4-3-11(9-13(12)18)23-8-7-22-6-5-21-2/h3-4,9,18H,5-8,10H2,1-2H3,(H,19,20)/t16-/m1/s1. InChi Key: YASYAEVZKXPYIZ-MRXNPFEDSA-N.