Sotalol-d6 (hydrochloride)

Sotalol-d6 (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay29097-1 1 mg -

6 - 10 business days*

417.00€
Cay29097-5 5 mg -

6 - 10 business days*

1,357.00€
 
Sotalol-d6 is intended for use as an internal standard for the quantification of sotalol... more
Product information "Sotalol-d6 (hydrochloride)"
Sotalol-d6 is intended for use as an internal standard for the quantification of sotalol (Cay-16136) by GC- or LC-MS. Sotalol is a non-selective antagonist of beta-adrenergic receptors (beta-ARs, IC50s = 8.9 and 5.2 µM for beta1- and beta2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 µM. Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES). Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).Formal Name: N-(4-(1-hydroxy-2-((propan-2-yl-1,1,1,3,3,3-d6)amino)ethyl)phenyl)methanesulfonamide, monohydrochloride. CAS Number: 1246820-85-8. Synonyms: MJ1999-d6, (±)-Sotalol-d6, DL-Sotalol-d6. Molecular Formula: C12H14D6N2O3S . HCl. Formula Weight: 314.9. Purity: >99% deuterated forms (d1-d6),. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble, Water: soluble. SMILES: CS(NC1=CC=C(C(O)CNC(C([2H])([2H])[2H])C([2H])([2H])[2H])C=C1)(=O)=O.Cl. InChi Code: InChI=1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17,/h4-7,9,12-15H,8H2,1-3H3,1H/i1D3,2D3,. InChi Key: VIDRYROWYFWGSY-TXHXQZCNSA-N.
Keywords: (±)-Sotalol-d6, DL-Sotalol-d6, MJ1999-d6, N-(4-(1-hydroxy-2-((propan-2-yl-1,1,1,3,3,3-d6)amino)ethyl)phenyl)methanesulfonamide, monohydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 29097

Properties

Application: GC-MS, LC-MS, internal standard, quantification, beta1/2-adrenergic receptor antagonist
MW: 314.9 D
Formula: C12H14D6N2O3S . HCl
Purity: >99% deuterated forms (d1-d6),
Format: Solid

Database Information

CAS : 1246820-85-8| Matching products
KEGG ID : K04141 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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