Sorafenib N-oxide

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
TGM-T36681-1mg	1 mg				7 - 10 business days*		295.00€
TGM-T36681-5mg	5 mg				7 - 10 business days*		980.00€

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Description: Sorafenib N-oxide is an active metabolite of sorafenib , an inhibitor of Raf-1,... more

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Product information "Sorafenib N-oxide"

Description: Sorafenib N-oxide is an active metabolite of sorafenib , an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD, Kd = 70 nM) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD (IC50 = 25.8 nM). It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3 (IC50s = 3.9-13.3 µM). Sorafenib N-oxide is also a linear-mixed inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 (Ki = 15 µM in human liver microsomes). Target: Others. Smiles: CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1=O

Supplier:	TargetMol
Supplier-Nr:	T36681

Properties

MW:	480.83 D
Formula:	C21H16ClF3N4O4

Database Information

CAS :

583840-03-3| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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