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Sonepiprazole is a selective antagonist of the dopamine 4 (D4) receptor (Kis = 10 nM). It is highly selective over D1, D2, and D3 receptors, serotonin 1A and 2 receptors, as well as alpha1- and alpha2-adrenergic receptors (Kis > 2,000 nM). Its safety profile in rat studies is improved in comparison to classical antipsychotics but it is not effective for positive or negative symptoms of schizophrenia in patients. In a pharmacological model of stress exposure in rhesus monkeys, sonepiprazole reverses stress-induced cognitive deficits.Formal Name: 4-[4-[2-[(1S)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl]-1-piperazinyl]-benzenesulfonamide. CAS Number: 170858-33-0. Synonyms: PNU 101387, U-101387. Molecular Formula: C21H27N3O3S. Formula Weight: 401.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 265 nm. SMILES: O=S(C(C=C1)=CC=C1N(CC2)CCN2CC[C@H]3C(C=CC=C4)=C4CCO3)(N)=O. InChi Code: InChI=1S/C21H27N3O3S/c22-28(25,26)19-7-5-18(6-8-19)24-14-12-23(13-15-24)11-9-21-20-4-2-1-3-17(20)10-16-27-21/h1-8,21H,9-16H2,(H2,22,25,26)/t21-/m0/s1. InChi Key: WNUQCGWXPNGORO-NRFANRHFSA-N.
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