Sodium Orthovanadate

Sodium orthovanadate is a protein tyrosine phosphatase inhibitor. It inhibits autocrine growth of A549 lung, A498 kidney, and DU145 prostate cancer cells when used at concentrations ranging from 1 to 20 µM. Sodium orthovanadate (20 mg/kg) protects mice from radiation-induced hematopoietic and gastrointestinal syndromes. It reduces postprandial glucose levels and increases glucose tolerance in a rat model of diabetes induced by streptozotocin (Cay-13104) when administered ad libitum in drinking water at a concentration of 0.5 mg/ml. Sodium orthovanadate also decreases total and cortical infarct size in a rat model of ischemia-reperfusion injury induced by transient middle cerebral artery occlusion (MCAO).Formal Name: sodium vanadium oxide. CAS Number: 13721-39-6. Synonyms: NSC 79534. Molecular Formula: Na3O4V. Formula Weight: 183.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: slightly soluble. SMILES: O=[V]([O-])([O-])[O-].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/3Na.4O.V/q3*+1,,3*-1,. InChi Key: IHIXIJGXTJIKRB-UHFFFAOYSA-N.