SN-38
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Larger quantity required? Request bulk
Description: SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I)... more
Product information "SN-38"
Description: SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 µM). SN-38 has antitumor activity and induces autophagy. Target: Autophagy, Topoisomerase, DNA/RNA Synthesis, ADC Cytotoxin. Smiles: C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(O)=CC5. References: Maurya DK, et al. Topoisomerase I inhibitor SN-38 effectively attenuates growth of human non-small cell lung cancer cell lines in vitro and in vivo. J Environ Pathol Toxicol Oncol. 2011,30(1):1-10.
| Keywords: | NK012, SN 38 |
| Supplier: | TargetMol |
| Supplier-Nr: | T1703 |
Properties
| Application: | Topoisomerase I inhibitor |
| MW: | 392.4 D |
| Formula: | C22H20N2O5 |
Database Information
| CAS : | 86639-52-3| Matching products |
| KEGG ID : | K03163 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301 |
| P Phrases: | P264, P270, P301+310, P321, P330, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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