SMI-16a

SMI-16a is a Pim-1 kinase inhibitor (IC50 = 63 nM). It is selective for Pim-1 over a panel of 60 kinases. SMI-16a (5 µM) inhibits phosphorylation of the Pim-1 target protein Bad in DU145-Pim cells and inhibits the growth of PC3, DU145, LNCaP, K562, and MV4-11 cancer cells. It induces apoptosis and cell cycle arrest at the G1 phase in DU145 cells.Formal Name: 5-[(4-propoxyphenyl)methylene]-2,4-thiazolidinedione. CAS Number: 587852-28-6. Molecular Formula: C13H13NO3S. Formula Weight: 263.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: CCCOC1=CC=C(/C=C2C(NC(S\2)=O)=O)C=C1. InChi Code: InChI=1S/C13H13NO3S/c1-2-7-17-10-5-3-9(4-6-10)8-11-12(15)14-13(16)18-11/h3-6,8H,2,7H2,1H3,(H,14,15,16)/b11-8+. InChi Key: GBWOSXZUTXXXQF-DHZHZOJOSA-N.