SM-324405

SM-324405 is a toll-like receptor 7 (TLR7) agonist (EC50 = 50.1 nM in a reporter assay using HEK293 cells expressing the human receptor). It is selective for TLR7 over TLR8 (EC50 = >10 µM). SM-324405 induces IFN production in isolated human peripheral blood mononuclear cells (PBMCs) with a minimum effective concentration (MEC) of 10 nM. It induces proliferation of isolated mouse, rat, and dog splenocytes (EC50s = 3.98, 6.31, and 12.59 nM, respectively). SM-324405 (0.1 and 1 mg/kg, intratracheally) inhibits bronchoalveolar lavage fluid (BALF) eosinophil infiltration in a rat model of ovalbumin-sensitized and -challenged allergic airway inflammation.Formal Name: 3-[(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)methyl]-benzeneacetic acid, methyl ester. CAS Number: 677773-91-0. Molecular Formula: C19H23N5O4. Formula Weight: 385.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100 mM. lambdamax: 282 nm. SMILES: NC1=C2C(N(CC3=CC(CC(OC)=O)=CC=C3)C(N2)=O)=NC(OCCCC)=N1. InChi Code: InChI=1S/C19H23N5O4/c1-3-4-8-28-18-22-16(20)15-17(23-18)24(19(26)21-15)11-13-7-5-6-12(9-13)10-14(25)27-2/h5-7,9H,3-4,8,10-11H2,1-2H3,(H,21,26)(H2,20,22,23). InChi Key: MXILFZWMVNDOIZ-UHFFFAOYSA-N.