SKF 82958 (hydrobromide)

SKF 82958 is a dopamine D1 receptor agonist (K0.5 = 4 nM in a radioligand binding assay). It is selective for dopamine D1 over D2 receptors (K0.5 = 73 nM). SKF 82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50 = 491 nM). SKF 82958 (3 mg/kg) prevents and reverses fentanyl-induced respiratory depression, without affecting analgesia, in cats. It also increases locomotion and rearing in rats.Formal Name: 6-chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)-1H-3-benzazepine-7,8-diol, monohydrobromide. CAS Number: 74115-01-8. Synonyms: (±)-6-chloro-APB. Molecular Formula: C19H20ClNO2 . HBr. Formula Weight: 410.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Water: 5 mM, with warming. SMILES: C=CCN1CCC2=C(Cl)C(O)=C(O)C=C2C(C3=CC=CC=C3)C1.Br. InChi Code: InChI=1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13,/h2-7,11,16,22-23H,1,8-10,12H2,1H. InChi Key: WLXGFAVTAAQOFH-UHFFFAOYSA-N.