SKA-31

SKA-31 is an activator of the small- and intermediate conductance calcium-activated potassium channels KCa2.1, KCa2.2, KCa2.3, and KCa3.1 (EC50s = 2.9, 1.9, 2.9, and 0.26 µM, respectively, in a patch-clamp assay). It also blocks the voltage-gated potassium (Kv) channels Kv1.3, Kv1.5, Kv3.1, and Kv3.2 by 10 to 30% and the voltage-gated sodium (Nav) channels Nav1.2, Nav1.4, and Nav1.5 by 9 to 40% in a panel of 13 ion channels when used at a concentration of 25 µM. SKA-31 increases vasodilation induced by acetylcholine (Cay-23829) in isolated mouse carotid artery (EC50 = 93 nM) and induces relaxation of isolated rat mesenteric artery rings precontracted with phenylephrine (IC50 = 93 nM). It decreases blood pressure in normotensive and angiotensin II-induced hypertensive mice when administered at a dose of 30 mg/kg.Formal Name: naphtho[1,2-d]thiazol-2-amine. CAS Number: 40172-65-4. Synonyms: 2-Aminonaphthiazole. Molecular Formula: C11H8N2S. Formula Weight: 200.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMSO: 15mg/mL, DMSO:PBS (pH 7.2) (1:5): 0.16mg/mL, Ethanol: 3mg/mL. SMILES: NC1=NC2=C(S1)C=CC3=CC=CC=C32. InChi Code: InChI=1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13). InChi Key: FECQXVPRUCCUIL-UHFFFAOYSA-N.