(-)-Sitagliptin Carbamoyl Glucuronide

(-)-Sitagliptin carbamoyl glucuronide is a minor phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin (Cay-13252). (-)-Sitagliptin carbamoyl glucuronide is formed by N-carbamoyl glucuronidation and has been found in rat and dog plasma following administration of (-)-sitagliptin.Formal Name: 1-[N-[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]carbamate] beta-D-glucopyranuronic acid. CAS Number: 940002-59-5. Synonyms: (R)-Sitagliptin Carbamoyl Glucuronide. Molecular Formula: C23H23F6N5O9. Formula Weight: 627.5. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: Water: soluble. SMILES: FC1=CC(C[C@@H](NC(O[C@@H]2O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]2O)=O)CC(N3CC4=NN=C(C(F)(F)F)N4CC3)=O)=C(F)C=C1F. InChi Code: InChI=1S/C23H23F6N5O9/c24-10-6-12(26)11(25)4-8(10)3-9(30-22(41)43-20-17(38)15(36)16(37)18(42-20)19(39)40)5-14(35)33-1-2-34-13(7-33)31-32-21(34)23(27,28)29/h4,6,9,15-18,20,36-38H,1-3,5,7H2,(H,30,41)(H,39,40)/t9-,15+,16+,17-,18+,20+/m1/s1. InChi Key: GKDZQUQEXZXGMZ-KUVPMCASSA-N.