SirReal2

Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and alpha-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation. SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM). SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6. This compound has been shown to be active in HeLa cells by significantly increasing alpha-tubulin acetylation.Formal Name: 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]-acetamide. CAS Number: 709002-46-0. Molecular Formula: C22H20N4OS2. Formula Weight: 420.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 3 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 247, 282 nm. SMILES: CC1=NC(SCC(NC2=NC=C(CC3=C(C=CC=C4)C4=CC=C3)S2)=O)=NC(C)=C1. InChi Code: InChI=1S/C22H20N4OS2/c1-14-10-15(2)25-22(24-14)28-13-20(27)26-21-23-12-18(29-21)11-17-8-5-7-16-6-3-4-9-19(16)17/h3-10,12H,11,13H2,1-2H3,(H,23,26,27). InChi Key: MENNDDDTIIZDDN-UHFFFAOYSA-N.