Siremadlin

Item number	Size	Delivery time	Price
TGM-T5555-1mg	1 mg	7 - 10 business days*	60.00€
TGM-T5555-5mg	5 mg	7 - 10 business days*	133.00€
TGM-T5555-1mL	1 ml	7 - 10 business days*	164.00€
TGM-T5555-10mg	10 mg	7 - 10 business days*	195.00€
TGM-T5555-25mg	25 mg	7 - 10 business days*	361.00€
TGM-T5555-50mg	50 mg	7 - 10 business days*	592.00€

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Description: Siremadlin (NVP-HDM 201) is a potent, orally bioavailable and highly specific... more

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Product information "Siremadlin"

Description: Siremadlin (NVP-HDM 201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor. Target: E1/E2/E3 Enzyme. Smiles: COc1ncc(-c2nc3C(=O)N([C@H](c3n2C(C)C)c2ccc(Cl)cc2)c2cc(Cl)cn(C)c2=O)c(OC)n1. References: Chapeau EA, et al. Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/- mouse model. Proc Natl Acad Sci U S A. 2017 Mar 21,114(12):3151-3156.

Keywords:	NVP-HDM 201
Supplier:	TargetMol
Supplier-Nr:	T5555

Properties

Application:	Targets E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27] (MDM2)
MW:	555.41 D
Formula:	C26H24Cl2N6O4
Format:	32160405

Database Information

CAS :	1448867-41-1\| Matching products
KEGG ID :	K06643 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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