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Sinomenine is an alkaloid isolated from the Chinese medicinal plant Sinomenium acutum. It has immunomodulating and anti-inflammatory activities. Its anti-arthritic propery is related to the antiproliferative effects on synovial fibroblasts and lymphocytes. Other antirheumatic mechanisms are attributed to its ability to decrease PGE2 and leukotriene C4 synthesis, and inhibit NO production. It also prevents myocardial injury by lowering intracellular Ca2 accumulation.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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