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White to off-white powder. Soluble in water (30mg/ml). Soluble in DMSO, ethanol or DMF (all 10mg/ml). Chemical. CAS: 101314-97-0. Formula: C25H39O6 . Na. MW: 458.6. Synthetic analog of Lovastatin (Prod. No. AG-CN2-0051 http://www.adipogen.com/ag-cn2-0051/lovastatin.html ). Water-soluble carboxylate form of Simvastatin (Prod.No. AG-CN2-0052 https://adipogen.com/ag-cn2-0052-simvastatin.html ). Potent competitive HMG-CoA reductase inhibitor [1]. Anti-hypercholesterolemic agent [1]. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids [1, 2]. Inhibits the isoprenylation of Ras and Rho family GTPases [2]. Smooth muscle cell proliferation inhibitor [3]. Anti-adhesive, immunomodulatory and anti-inflammatory compound [4, 7, 10]. Proteasome modulator [5]. Stimulates bone formation [6]. Apoptosis inducer [8]. Anticancer compound [8, 9]. Increases cellular resistance to anticancer agents such as doxorubicin and etoposides (Prod. No. AG-CR1-3572 http://www.adipogen.com/ag-cr1-3572/etoposide.html ) [9]. Suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection [11, 12]. Anti-hypertensive agent [13]. Suppresses TNF-induced NF-kappaB activation [14].
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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