SH-4-54

SH-4-54
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay25982-1 1 mg -

6 - 10 business days*

43.00€
Cay25982-5 5 mg -

6 - 10 business days*

146.00€
Cay25982-10 10 mg -

6 - 10 business days*

267.00€
Cay25982-25 25 mg -

6 - 10 business days*

510.00€
 
SH-4-54 is an inhibitor of signal transducer and activator of transcription 3 (STAT3, IC50 = 4.7... more
Product information "SH-4-54"
SH-4-54 is an inhibitor of signal transducer and activator of transcription 3 (STAT3, IC50 = 4.7 µM for STAT3 homodimer DNA binding activity). It selectively inhibits STAT3 homodimer over STAT1 and STAT5 homodimer and STAT3:STAT1 heterodimer DNA binding in EGF-stimulated NIH3T3/hEGFR nuclear extracts containing activated STAT1, STAT3, and STAT5 and decreases STAT3 iNOS, Survivin, and Bcl-2 promoter occupancy in MDA-MB-231 cells. SH-4-54 inhibits growth of glioma, breast, and prostate cancer cell lines that express constitutively active STAT3 (IC50s = 1-7.4, 3.8-4.5, and 5.3-5.8 µM, respectively). In vivo, SH-4-54 (3 mg/kg per day) inhibits tumor growth in the U251MG glioma and MDA-MB-231 breast cancer mouse xenograft models.Formal Name: 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-benzoic acid. CAS Number: 1456632-40-8. Molecular Formula: C29H27F5N2O5S. Formula Weight: 610.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml. SMILES: O=C(O)C1=CC=C(N(C(CN(C)S(C2=C(F)C(F)=C(F)C(F)=C2F)(=O)=O)=O)CC3=CC=C(C4CCCCC4)C=C3)C=C1. InChi Code: InChI=1S/C29H27F5N2O5S/c1-35(42(40,41)28-26(33)24(31)23(30)25(32)27(28)34)16-22(37)36(21-13-11-20(12-14-21)29(38)39)15-17-7-9-19(10-8-17)18-5-3-2-4-6-18/h7-14,18H,2-6,15-16H2,1H3,(H,38,39). InChi Key: VFPYGNNOSJWBHF-UHFFFAOYSA-N.
Keywords: 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-benzoic acid
Supplier: Cayman Chemical
Supplier-Nr: 25982

Properties

Application: STAT3 inhibitor
MW: 610.6 D
Formula: C29H27F5N2O5S
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 1456632-40-8| Matching products
KEGG ID : K04692 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335
P Phrases: P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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