SGX-523

Item number	Size	Manual	Delivery time	Price
SYN-1155-M001	1 mg	-	3 - 9 business days*	132.00€
SYN-1155-M005	5 mg	-	3 - 9 business days*	218.00€
SYN-1155-M010	10 mg	-	3 - 9 business days*	362.00€
SYN-1155-M050	50 mg	-	3 - 9 business days*	1,087.00€
SYN-1155-M100	100 mg	-	3 - 9 business days*	-

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Soluble in DMSO. Slightly soluble ( 36%, suggesting IC(50) values > 1µM, including the... more

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Product information "SGX-523"

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. SGX523 is an ATP-competitive, triazolopyridazine-based inhibitor of MET at an IC(50) of 4nM. SGX523 has higher affinity for the unphosphorylated form of MET (Ki = 2.7nM) than the more active phospho-enzyme (Ki = 23nM). In a broad panel of 213 kinases, SGX523 was extremely selective, with no inhibition >36%, suggesting IC(50) values > 1µM, including the closely-associated RON kinase. Target: c-Met , Kinase Group: RTK , Substrate: Tyrosine

Keywords:	SGX523
Supplier:	SYNkinase
Supplier-Nr:	1155

Properties

Application:	c-Met inhibitor
MW:	359,4 D
Formula:	C18H13N7S
Purity:	>95%
Format:	Solid

Database Information

CAS :	1072116-01-8\| Matching products
KEGG ID :	K05099 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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