SGLT inhibitor-1

Description: SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively). Target: SGLT. Smiles: O(C)C=1C(=CC(CC=2C=C3C(=CC2)OCCO3)=C4C1CCO4)[C@@H]5O[C@H](CO)[C@@H](F)[C@H](O)[C@H]5O. References: Xu G, et al. Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors. Bioorg Med Chem Lett. 2018 Nov 15,28(21):3446-3453.