Senkyunolide H

Senkyunolide H is a phthalide that has been found in L. chuanxiong and has diverse biological activities. It increases levels of heme oxygenase-1 (HO-1) in HepG2 cells, as well as reduces hydrogen peroxide-induced increases in reactive oxygen species (ROS) and malondialdehyde (MDA) in the same cells when used at concentrations of 150 and 200 µg/ml. Senkyunolide H inhibits the proliferation of primary mouse aorta smooth muscle cells (IC50 = <0.1 µg/ml). It decreases bone resorption in ovariectomized mice when administered at a dose of 15 mg/kg.Formal Name: (3Z,6R,7S)-rel-3-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-1(3H)-isobenzofuranone. CAS Number: 94596-27-7. Molecular Formula: C12H16O4. Formula Weight: 224.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble. lambdamax: 274 nm. SMILES: O[C@H]1C2=C(CC[C@H]1O)/C(OC2=O)=C/CCC. InChi Code: InChI=1S/C12H16O4/c1-2-3-4-9-7-5-6-8(13)11(14)10(7)12(15)16-9/h4,8,11,13-14H,2-3,5-6H2,1H3/b9-4-/t8-,11-/m1/s1. InChi Key: DQNGMIQSXNGHOA-OBEBJBLMSA-N. Origin: Plant/Angelica sinensis.