Senkyunolide A

Senkyunolide A is a phthalide originally isolated from celery seed essential oil that has cytoprotective and antiproliferative activities. It protects against cell injury induced by corticosterone in PC12 cells in a time-dependent manner when used at concentrations ranging from 0.125 to 0.5 mg/ml and reduces corticosterone-induced apoptosis at a concentration of 0.5 mg/ml. It also reverses increases in protein levels of phosphatase 2A (PP2A) and alpha-synuclein and reverses decreases in the phosphorylated forms of PP2A and alpha-synuclein. Senkyunolide A inhibits cell proliferation of HT-29 colon cancer (IC50 = 54.17 µM) but not non-cancerous human CCD-18Co colon cells (IC50 = 109.11 µM).Formal Name: (3S)-3-butyl-4,5-dihydro-1(3H)-isobenzofuranone. CAS Number: 63038-10-8. Synonyms: (-)-Sedanenolide, (S)-Sedanenolide. Molecular Formula: C12H16O2. Formula Weight: 192.3. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 278 nm. SMILES: O=C1O[C@@H](CCCC)C2=C1C=CCC2. InChi Code: InChI=1S/C12H16O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h5,7,11H,2-4,6,8H2,1H3/t11-/m0/s1. InChi Key: ZPIKVDODKLJKIN-NSHDSACASA-N. Origin: Plant/Ligusticum chuanxiong Hort..