Senicapoc
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel that ameliorates... more
Product information "Senicapoc"
Description: Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel that ameliorates RBC dehydration in the SAD mouse. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 = 100 ± 12 nM) and inhibits RBC dehydration with an IC50 of 30 ± 20 nM. Senicapoc is used in the treatment of Sickle Cell Disease and Sickle Cell Anemia. Target: Potassium Channel. Smiles: NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1. References: Stocker JW, et al. ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice. Blood. 2003 Mar 15,101(6):2412-8.
| Keywords: | ICA-17043 |
| Supplier: | TargetMol |
| Supplier-Nr: | T3528 |
Properties
| Application: | Targets phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta |
| MW: | 323.34 D |
| Formula: | C20H15F2NO |
Database Information
| CAS : | 289656-45-7| Matching products |
| KEGG ID : | K04945 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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