Sedanolide

Sedanolide is a natural phthalide first isolated from seed oil of the Umbelliferae family, including celery. It induces the expression of glutathione S-transferase and reduces chemical-induced carcinogenesis in mice. Sedanolide inhibits cyclooxygenases-1 and -2 at 250 pg/ml and blocks topoisomerase-I and-II activity at 100 µg/ml. It is mosquitocidal, nematicidal, and antifungal but shows no cytotoxicity against normal mammalian cells.Formal Name: 3-butyl-3a,4,5,6-tetrahydro-1(3H)-isobenzofuranone. CAS Number: 6415-59-4. Molecular Formula: C12H18O2. Formula Weight: 194.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 219 nm. SMILES: O=C1OC(CCCC)C2CCCC=C21. InChi Code: InChI=1S/C12H18O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h7,9,11H,2-6,8H2,1H3. InChi Key: UPJFTVFLSIQQAV-UHFFFAOYSA-N. Origin: Synthetic.