Scoulerine

Scoulerine is a benzylisoquinoline alkaloid that has been found in C. cava and has diverse biological activities. It selectively binds to the dopamine D1 and D2 receptors (Kis = 22 and 214 nM, respectively) over the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2A in HEK293 cells when used at a concentration of 10 µM. Scoulerine inhibits proliferation in a panel of leukemia cell lines (IC50s = 2.7-6.5 µM). It inhibits methamphetamine-induced conditioned place preference in mice when administered at a dose of 5 mg/kg.Formal Name: 5,8,13,13aS-tetrahydro-3,10-dimethoxy-6H-dibenzo[a,g]quinolizine-2,9-diol. CAS Number: 6451-73-6. Synonyms: (-)-Scoulerine, l-Scoulerine, (S)-Scoulerine. Molecular Formula: C19H21NO4. Formula Weight: 327.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: Slightly Soluble, Methanol: Slightly Soluble. SMILES: OC1=C(OC)C=C2CCN(CC3=C(O)C(OC)=CC=C3C4)[C@]4([H])C2=C1. InChi Code: InChI=1S/C19H21NO4/c1-23-17-4-3-11-7-15-13-9-16(21)18(24-2)8-12(13)5-6-20(15)10-14(11)19(17)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3/t15-/m0/s1. InChi Key: KNWVMRVOBAFFMH-HNNXBMFYSA-N. Origin: Synthetic.