SCH 58261

SCH 58261 is a competitive antagonist of the adenosine A2A receptor (Kis = 2.3 and 2.0 nM in rat and bovine brain, respectively). It is selective for the A2A subtype, displaying an A1/A2A selectivity ratio of 50-100-fold and does not interact with A2B or A3 receptors. SCH 58261 has been used to improve 6-hydroxy dopamine-induced motor deficits in a rat model of Parkinson's disease.Formal Name: 2-(2-furanyl)-7-(2-phenylethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine. CAS Number: 160098-96-4. Molecular Formula: C18H15N7O. Formula Weight: 345.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml, DMSO: 10 mg/ml. lambdamax: 232, 262 nm. SMILES: NC(N1C2=NC(C3=CC=CO3)=N1)=NC4=C2C=NN4CCC5=CC=CC=C5. InChi Code: InChI=1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22). InChi Key: UTLPKQYUXOEJIL-UHFFFAOYSA-N.