SCH 28080

SCH 28080 is a reversible K+-competitive inhibitor of H+/K+-ATPases that is best known for its ability to block acid secretion through its action against the gastric H+/K+-ATPase (IC50 = 1.3 µM). It is effective against gastric H+/K+-ATPases from a variety of species and can inhibit colonic H+/K+-ATPases, but this activity appears to be species-dependent. SCH 28080 is also used to investigate the role of H+/K+-ATPases in non-mammalian organisms and to distinguish the actions of H+/K+-ATPases from other ATP-dependent transporters.Formal Name: 2-methyl-8-(phenylmethoxy)-imidazo[1,2-a]pyridine-3-acetonitrile. CAS Number: 76081-98-6. Molecular Formula: C17H15N3O. Formula Weight: 277.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 229, 235, 280 nm. SMILES: CC1=C(CC#N)N(C2=N1)C=CC=C2OCC3=CC=CC=C3. InChi Code: InChI=1S/C17H15N3O/c1-13-15(9-10-18)20-11-5-8-16(17(20)19-13)21-12-14-6-3-2-4-7-14/h2-8,11H,9,12H2,1H3. InChi Key: PYKJFEPAUKAXNN-UHFFFAOYSA-N.