SB-271046 (hydrochloride)

SB-271046 is an orally-available antagonist of the serotonin (5-hydroxytryptamine, or 5-HT, Cay-14332) receptor 5-HT6 (pKi = 9.02-8.92). It is at least 100-fold selective for 5-HT6 over other 5-HT receptors, as well as 55 other receptors, enzymes, and ion channels. While it does not alter basal levels of 5-HT, dopamine, or noradrenaline, SB-271046 produces a significant increase in extracellular levels of glutamate and aspartate within the frontal cortex. It has been used to evaluate the role of 5-HT6 in learning and memory.Formal Name: 5-chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methyl-benzo[b]thiophene-2-sulfonamide, monohydrochloride. CAS Number: 209481-24-3. Molecular Formula: C20H22ClN3O3S2 . HCl. Formula Weight: 488.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 10 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 211, 241, 282 nm. SMILES: ClC1=CC=C2C(C(C)=C(S(NC3=CC(N4CCNCC4)=C(OC)C=C3)(=O)=O)S2)=C1.Cl. InChi Code: InChI=1S/C20H22ClN3O3S2.ClH/c1-13-16-11-14(21)3-6-19(16)28-20(13)29(25,26)23-15-4-5-18(27-2)17(12-15)24-9-7-22-8-10-24,/h3-6,11-12,22-23H,7-10H2,1-2H3,1H. InChi Key: RMXZRJYGJMSDQK-UHFFFAOYSA-N.