SB-269970 (hydrochloride)

The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine, 5-HT) is mediated by at least seven major 5-HT receptor subtypes. SB-269970 is a potent 5-HT7A antagonist (pKi = 8.9) that demonstrates >50-fold binding selectivity over 5-HT5A and >250-fold selectivity over 5-HT1, 5-HT2, 5-HT4, 5-HT6, adrenergic alpha1, dopamine D2, and dopamine D3 receptors. It is also reported to block adrenergic alpha2 receptors in guinea pig vas deferens. SB-269970 has been used to target the 5-HT7 receptor in the study of schizophrenia-like cognitive deficits.Formal Name: 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-phenol, monohydrochloride. CAS Number: 261901-57-9. Molecular Formula: C18H28N2O3S . HCl. Formula Weight: 389.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 286 nm. SMILES: OC1=CC=CC(S(N2CCC[C@@H]2CCN3CCC(C)CC3)(=O)=O)=C1.Cl. InChi Code: InChI=1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18,/h2,5-6,14-16,21H,3-4,7-13H2,1H3,1H/t16-,/m1./s1. InChi Key: XQCJOYZLWFNDIO-PKLMIRHRSA-N.