Sarafloxacin (hydrochloride)

Sarafloxacin is a fluoroquinolone antibiotic. It is active against various clinical isolates of bacteria, including Bacteroides, Fusobacterium, Eubacterium, Actinomyces, and Peptococcus (MICs = 0.5-2 µg/ml). Sarafloxacin inhibits P. aeruginosa DNA gyrase. It decreases air sac lesion severity in a chick model of E. coli-induced colisepticemia when administered at a dose of 8 mg/kg in the drinking water 24 hours per day for five days. Formulations containing sarafloxacin have previously been used in the treatment of bacterial infections in poultry.Formal Name: 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, monohydrochloride. CAS Number: 91296-87-6. Synonyms: A-56620. Molecular Formula: C20H17F2N3O3 . HCl. Formula Weight: 421.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 2 mg/ml, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 280, 318, 330 nm. SMILES: O=C1C2=CC(F)=C(N3CCNCC3)C=C2N(C4=CC=C(F)C=C4)C=C1C(O)=O.Cl. InChi Code: InChI=1S/C20H17F2N3O3.ClH/c21-12-1-3-13(4-2-12)25-11-15(20(27)28)19(26)14-9-16(22)18(10-17(14)25)24-7-5-23-6-8-24,/h1-4,9-11,23H,5-8H2,(H,27,28),1H. InChi Key: KNWODGJQLCISLC-UHFFFAOYSA-N.