Saracatinib, Free Base (N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(ox

Saracatinib an orally available Src kinase inhibitor. Saracatinib inhibits c-Src and Abl enzymes at low nanomolar concentrations. Saracatinib blocked the tumor growth of a c-Src-transfected 3T3-fibroblast xenograft in vivo and increased significantly the survival of animals in a highly aggressive model of human pancreatic cancer. Solubility: Soluble in DMSO at 200mg/ml, soluble in ethanol at 200mg/ml, very poorly soluble in water, maximum solubility in plain water is estimated to be about 20-100uM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 6 months after receipt.