SAR7334 (hydrochloride)

SAR7334 is a transient receptor potential canonical 6 (TRPC6) channel blocker (IC50 = 7.9 nM). It is selective for TRPC6 over TRPC4 and TRPC5 (IC50s = 282 and 226 nM, respectively). SAR7334 (0.2-1 µM) blocks TRPC6-dependent hypoxia-induced vasoconstriction in isolated perfused and ventilated mouse lung. It also inhibits oxidative stress-induced apoptosis and increases autophagic flux in primary mouse renal proximal tubule cells.Formal Name: 4-[[(1R,2R)-2-[(3R)-3-amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-benzonitrile, dihydrochloride. CAS Number: 1333207-63-8. Molecular Formula: C21H22ClN3O . 2HCl. Formula Weight: 440.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/mL, DMSO: 15 mg/mL, Ethanol: 25 mg/mL, Ethanol:PBS (pH 7.2) (1:5): 0.16mg/mL. lambdamax: 211, 254 nm. SMILES: N[C@H](CCC1)CN1[C@H]2[C@H](OC3=C(Cl)C=C(C#N)C=C3)C4=CC=CC=C4C2.Cl.Cl. InChi Code: InChI=1S/C21H22ClN3O.2ClH/c22-18-10-14(12-23)7-8-20(18)26-21-17-6-2-1-4-15(17)11-19(21)25-9-3-5-16(24)13-25,,/h1-2,4,6-8,10,16,19,21H,3,5,9,11,13,24H2,2*1H/t16-,19-,21-,,/m1../s1. InChi Key: LFMYIKNZNTZSJX-IQJQELQDSA-N.