Salvinorin A Propionate

Description: Salvinorin A propionate is a selective partial agonist at kappa1-opioid receptors (KOR) with a Ki value of 32.6 nM. It inhibits adenylate cyclase (EC50 = 4.7 nM) in HEK293 cells transfected with human KOR. It is selective for KORs over µ, delta, and ORL-1 opioid receptors and has no effect at serotonin, dopamine, muscarinic, or adrenergic receptors. In mice, salvinorin A propionate (13 µg, i.c.v.) reduces nociceptive responses in a radiant heat tail-flick assay, though not as potently as salvinorin A . Target: Others. Smiles: C[C@@]12[C@@]3([C@](C)([C@H](C(OC)=O)C[C@H](OC(CC)=O)C3=O)CC[C@]1(C(=O)O[C@@H](C2)C=4C=COC4)[H])[H]