Salsalate

Salsalate is a non-steroidal anti-inflammatory drug (NSAID) and prodrug form of salicylic acid. It is converted to salicylic acid by hydrolysis. It inhibits prostaglandin E2 (PGE2, Cay-14010) production in isolated human whole blood stimulated with LPS (IC50 = 39.9 µM). Salsalate (1,000 mg/kg) inhibits weight gain and decreases fasting plasma glucose and insulin levels, as well as decreases plasma cholesterol and triglyceride levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a high-fat high-cholesterol diet. Formulations containing salsalate have been used in the treatment of pain associated with osteoarthritis and rheumatoid arthritis.Formal Name: 2-hydroxy-2-carboxyphenyl ester-benzoic acid. CAS Number: 552-94-3. Synonyms: NSC 49171, Nobacid. Molecular Formula: C14H10O5. Formula Weight: 258.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 5 mg/ml, Ethanol: 3 mg/ml. lambdamax: 207, 234, 308 nm. SMILES: OC1=CC=CC=C1C(OC2=C(C(O)=O)C=CC=C2)=O. InChi Code: InChI=1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17). InChi Key: WVYADZUPLLSGPU-UHFFFAOYSA-N. Origin: Synthetic.