Salbutamol-d9

Salbutamol-d9 is intended for use as an internal standard for the quantification of salbutamol (Cay-21003, Cay-23991) by GC- or LC-MS. Salbutamol is an agonist of the beta2-adrenergic receptor (beta2-AR, Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor). It is selective for beta2-ARs over beta1- and beta3-ARs (Kds = 46.8 and 21.9 µM, respectively). Salbutamol (25-50 µg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs. It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 µg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 µg). Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).Formal Name: alpha1-[[[1,1-di(methyl-d3)ethyl-2,2,2-d3]amino]methyl]-4-hydroxy-1,3-benzenedimethanol. CAS Number: 1173021-73-2. Synonyms: (±)-Salbutamol-d9, DL-Salbutamol-d9. Molecular Formula: C13H12D9NO3. Formula Weight: 248.4. Purity: >99% deuterated forms (d1-d9). Formulation: (Request formulation change), A solid. Solubility: Methanol: Slightly Soluble, Water: Slightly Soluble. SMILES: OCC1=C(O)C=CC(C(O)CNC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C1. InChi Code: InChI=1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3/i1D3,2D3,3D3. InChi Key: NDAUXUAQIAJITI-GQALSZNTSA-N.