Salazinic Acid

Salazinic acid is a depsidone lichen metabolite that has been found in P. sulcata. It is active against B. cereus, B. subtilis, S. aureus, P. aeruginosa, S. typhimurium, C. albicans, and A. niger in vitro (MICs = 3.9-30.8 mM). Salazinic acid is cytotoxic to MM98, A431, and HaCaT cells in crystal violet (EC50s = 159, 2,870, and 48 µM, respectively) and neutral red uptake assays (EC50s = 1,925, 1,913, and 907 µM, respectively). It increases the wound closure rate in scratch-wounded HaCaT monolayers and increases HaCaT cell migration in a transwell assay when used at a concentration of 30 µM.Formal Name: 1,3-dihydro-1,4,10-trihydroxy-5-(hydroxymethyl)-8-methyl-3,7-dioxo-7H-isobenzofuro[4,5-b][1,4]benzodioxepin-11-carboxaldehyde. CAS Number: 521-39-1. Synonyms: NSC 87509. Molecular Formula: C18H12O10. Formula Weight: 388.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=CC1=C(O)C=C(C)C2=C1OC3=C(C(CO)=C(O)C4=C3C(O)OC4=O)OC2=O. InChi Code: InChI=1S/C18H12O10/c1-5-2-8(21)6(3-19)13-9(5)16(23)27-14-7(4-20)12(22)10-11(15(14)26-13)18(25)28-17(10)24/h2-3,18,20-22,25H,4H2,1H3. InChi Key: QQTKVXCQLZIJPP-UHFFFAOYSA-N. Origin: Fungus/Usnea sp..