SAHA

SAHA is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. It inhibits class I, II, and IV HDACs at 50-200 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.Formal Name: N1-hydroxy-N8-phenyl-octanediamide. CAS Number: 149647-78-9. Synonyms: Suberoylanilide Hydroxamic Acid, Vorinostat. Molecular Formula: C14H20N2O3. Formula Weight: 264.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 243 nm. SMILES: ONC(=O)CCCCCCC(=O)Nc1ccccc1. InChi Code: InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18). InChi Key: WAEXFXRVDQXREF-UHFFFAOYSA-N.