S1QEL1.1

S1QEL1.1 is a small molecule that suppresses superoxide production during reverse electron transport through the IQ site of the mitochondrial respiratory complex I (IC50 = 70 nM) without affecting oxidative phosphorylation. It diminishes endogenous oxidative damage in primary astrocytes, reduces stress-induced signaling in a cardiomyocyte cell model, and protects against ischemia-reperfusion injury in perfused mouse heart.Formal Name: N1-(3-acetamidophenyl)-N2-(2-(4-methyl-2-(p-tolyl)thiazol-5-yl)ethyl)oxalamide. CAS Number: 897613-29-5. Synonyms: S1QEL. Molecular Formula: C23H24N4O3S. Formula Weight: 436.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml, DMSO: 2 mg/ml. lambdamax: 240, 299 nm. SMILES: CC(NC1=CC=CC(NC(C(NCCC2=C(C)N=C(C3=CC=C(C)C=C3)S2)=O)=O)=C1)=O. InChi Code: InChI=1S/C23H24N4O3S/c1-14-7-9-17(10-8-14)23-25-15(2)20(31-23)11-12-24-21(29)22(30)27-19-6-4-5-18(13-19)26-16(3)28/h4-10,13H,11-12H2,1-3H3,(H,24,29)(H,26,28)(H,27,30). InChi Key: BFNBJUBXXJKBFN-UHFFFAOYSA-N.