(S)-Pramipexole (hydrochloride)

(S)-Pramipexole is a dopamine D2S, D2L, D3, and D4 receptor agonist (EC50s = 426.58, 338.84, 2.24, and 128.82 nM, respectively, in a [35S]GTPgammaS binding assay). It is also a partial agonist of alpha2A-adrenergic receptors (alpha2A-ARs, EC50 = 3,548.13 nM). (S)-Pramipexole is selective for dopamine D2-4 receptors (Kis = 954.99, 1,698.24, 12.59, 128.82 nM for for D2S, D2L, D3, and D4 receptors, respectively, in a radioligand binding assay) over D1 and D5 receptors (Kis = >10,000 nM for both). It prevents MPTP-induced decreases in the number of dopaminergic neurons in the substantia nigra pars compacta in common marmosets when administered at a dose of 60 µg/kg per day before, during, and after administration of MPTP. Formulations containing (S)-pramipexole have been used in the treatment of Parkinson's disease and restless legs syndrome.Formal Name: (6S)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine, dihydrochloride. CAS Number: 104632-25-9. Synonyms: (-)-Pramipexole. Molecular Formula: C10H17N3S . 2HCl. Formula Weight: 284.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 220, 264 nm. SMILES: NC(S1)=NC2=C1C[C@@H](NCCC)CC2.Cl.Cl. InChi Code: InChI=1S/C10H17N3S.2ClH/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8,,/h7,12H,2-6H2,1H3,(H2,11,13),2*1H/t7-,,/m0../s1. InChi Key: QMNWXHSYPXQFSK-KLXURFKVSA-N.