S-Nitrosoglutathione

S-Nitroso-L-glutathione is an S-nitrosothiol NO donor based on naturally-occurring glutathione. It is a potent smooth muscle relaxant and inhibitor of platelet aggregation. Its stability in solution varies from seconds to hours depending on temperature, buffer composition and metal content. References: (1) M.W. Radomski, et al., Br. J. Pharmacol. 107, 745 (1992) , (2) W.R. Mathews & S.W. Kerr, J. Pharmacol. Exp. Ther. 267, 1529 (1993) , (1) E.A. Konorev, et al., J. Pharmacol. Exp. Ther. 274, 200 (1995) , (4) A. Gasco, et al., Farmaco 51, 617 (1996) , (5) J.A. Cook, et al., Anal. Biochem. 238, 150 (1996) , (6) A.R. Butler & P. Rhodes, Anal. Biochem. 249, 1 (1997) , (7) R. Motterlini, et al., J. Biol. Chem. 275, 13613 (2000) , (8) H. K. Jeon, et al., Cell. Biol. Toxicol. 21, 115 (2005) , (9) C.X. Yu, et al., Mol. Pharmacol. 68, 847 (2005) , (10) M. Khan, et. al., J. Cereb. Blood Flow Metab. 25, 177 (2005) , (11) D. McGrowder, et al., J. Biosci. 31, 347 (2006) , (12) R. Prasad, et al., Glia 55, 65 (2007) , (13) M. Mussbacher, et al., Sci. Rep. 9, 15403 (2019) Appearance: Pale pink powder. Solubility: Soluble in water (20 mg/ml) or DMSO (20mg/ml). Identity: Determined by 1H-NMR. Declaration: Manufactured by Chemodex. Inchi Key: HYHSBSXUHZOYLX-WDSKDSINSA-N Smiles: OC([C@@H](N)CCC(N[C@H](C(NCC(O)=O)=O)CSN=O)=O)=O