(S)-Lansoprazole

(S)-Lansoprazole is a proton pump inhibitor that irreversibly inhibits H+/K+-stimulated ATPase pumps in parietal cells (IC50 = 5.2 µM), inhibiting gastric acid secretion and increasing intragastric pH. It also inhibits acid formation in isolated canine parietal cells (IC50 = 82 µM). (S)-Lansoprazole is an enantiomerically pure form of lansoprazole (Cay-13627). Both (S)- and (R)-lansoprazole (Cay-18235) are pharmacologically active with similar potencies.Formal Name: 2-[(S)-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole. CAS Number: 138530-95-7. Synonyms: (-)-Lansoprazole. Molecular Formula: C16H14F3N3O2S. Formula Weight: 369.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 284 nm. SMILES: CC1=C(C[S@@](C2=NC(C=CC=C3)=C3N2)=O)N=CC=C1OCC(F)(F)F. InChi Code: InChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)/t25-/m0/s1. InChi Key: MJIHNNLFOKEZEW-VWLOTQADSA-N.