S-Acetyl-L-glutathione

Description: S-Acetyl-L-glutathione is a derivative of glutathione .1 It increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency when used at a concentration of 50 µM. S-Acetyl-L-glutathione (5 mM) induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells.2 It inhibits the replication of herpes simplex virus 1 (HSV-1) in human foreskin fibroblasts when used at concentrations of 5 and 10 mM.3 S-Acetyl-L-glutathione (6.25 µg/g per day) increases survival in a mouse model of HSV-1 infection. Target: Others. Smiles: CC(=O)SCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O. References: Okun, J.G., Sauer, S., B?hr, S., et al. S-Acetylglutathione normalizes intracellular glutathione content in cultured fibroblasts from patients with glutathione synthetase deficiency. J. Inherit. Metab. Dis. 27(6), 783-786 (2004).