(S)-3,5-DHPG

(S)-3,5-DHPG, known more commonly as DHPG, is an agonist of the group I metabotropic glutamate receptors (mGluRs), binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 µM, respectively) but not ionotropic glutamate receptors. The (S)-enantiomer is about ten times more potent than the (R)-enantiomer. (S)-3,5-DHPG is commonly used to evaluate the roles of group I mGluRs in neuronal signaling.Formal Name: (alphaS)-amino-3,5-dihydroxy-benzeneacetic acid. CAS Number: 162870-29-3. Synonyms: (S)-3,5-Dihydroxyphenylglycine. Molecular Formula: C8H9NO4. Formula Weight: 183.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 20 mg/ml, PBS (pH 7.2): 20 mg/ml. SMILES: OC1=CC([C@H](N)C(O)=O)=CC(O)=C1. InChi Code: InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)/t7-/m0/s1. InChi Key: HOOWCUZPEFNHDT-ZETCQYMHSA-N.